What is the difference between oxymorphone and hydromorphone




















If you suddenly stop taking it, you may experience withdrawal symptoms. Talk to your doctor before you stop taking either medication. Your doctor can help you taper off the medication slowly, which reduces the risk of withdrawal. Both of these drugs can also lead to overdose and are very dangerous for children. Keep your medication locked and away from any children in your household.

Because hydromorphone is so potent, it could be fatal if a child takes just one extended-release tablet. Hydromorphone comes with a black box warning on its label. This means research has found the drug may have serious and even life-threatening side effects.

Hydromorphone may also cause a drop in blood pressure. It should be used carefully, if at all, in individuals who already have low blood pressure or who take medications to lower their blood pressure.

Oxycodone also carries serious warnings. Like hydromorphone, oxycodone can enhance the depressant effects of alcohol. Oxycodone can also cause gastrointestinal complications. They can become habit-forming if taken consistently for weeks or months. You could find yourself taking more than the prescribed dose, or taking the drug more frequently than prescribed.

This means you may be becoming dependent on the drug. You may need to taper off the drug gradually. If you suddenly stop taking it, you could experience withdrawal.

Talk to your doctor to get help tapering off either medication. Hydromorphone is the more powerful medication. Your doctor will decide what kind of pain relief you need and will probably start you on a short-acting drug first.

Severe pain can have a debilitating effect on your quality of life. When these drugs are used as prescribed and for short periods of time, they can provide much needed relief. Methadone and Suboxone are both powerful opioid medications. Naproxen and acetaminophen both treat mild to moderate pain, but they work differently. Commonly people have some additional medication prescribed, called breakthrough medication. Morphine is the most commonly known pain medication. Hydromorphone is more potent than morphine, which simply means that a smaller quantity of hydromorphone has the same pain relieving effect as a larger quantity of morphine.

For example, someone taking 10 mg of morphine may be switched to 1 or 2 mg of hydromorphone. The degree of pain relief is the same. Both morphine and hydromorphone are used to treat moderate to severe pain.

Morphine is often the first medication used. For some patients, however, hydromorphone may be a better first choice. People who are older may have less trouble with side effects such as sleepiness or confusion with hydromorphone.

People whose kidneys are not fully functioning may also do better with hydromorphone, because it is removed from the body by the liver not the kidneys. A physician takes these factors into account when deciding which medication to use. Usually when people have become adjusted to a short-acting medication, they are switched to the slow-release form.

Article of the Year Award: Outstanding research contributions of , as selected by our Chief Editors. Read the winning articles.

Special Issues. Academic Editor: Anna Maria Aloisi. Received 01 Jun Revised 14 Sep Accepted 01 Oct Published 01 Nov Abstract Morphine has traditionally been considered the first line agent for analgesia in hospitals; however, in the last few years there has been a shift towards the use of hydromorphone as a first line agent.

Introduction In , it was reported that approximately 9 in 10 Americans frequently experience pain [ 1 ]. Results 3. Demographics Averages for demographics were calculated across all three years for patients treated with morphine or hydromorphone. Medical and Surgical Groups Over the three years, , patients were treated with hydromorphone and , patients were treated with morphine. Use of Hydromorphone and Morphine Over the three-year study period, the use of morphine steadily decreased while use of hydromorphone increased in both medical and surgical groups.

Figure 1. Table 1. Table 2. Outcomes by medical surgical and hydromorphone and morphine. View at: Google Scholar J. Dahl and D. View at: Google Scholar R. Mularski, F. White-Chu, D. Overbay, L. Miller, S. Asch, and L. Fox, D. Berger, P. Fine et al. View at: Google Scholar H.

Vila Jr. Smith, M. Augustyniak et al. View at: Google Scholar A. Chang, P. Bijur, R. Meyer, M. Kenny, C. Solorzano, and E. Felden, C. Walter, S. Harder et al. Hong, P. Flood, and G. Ogura and T. Hemmings and T. Egan, Eds. View at: Google Scholar C.

View at: Google Scholar P. Glare and T. Hill, B. Coda, A. Tanaka, and R. Wright, L.



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